What is the Latest on Dyslipidemia and Dietary Supplements?
The Question
How beneficial are dietary supplements (e.g. berberine, coenzyme Q10, garlic, guggul, lecithin, niacin, policosanol, red clover, red yeast rice, rice bran oil) in the treatment of dyslipidemia?
Key Practice Point #1: Berberine
Recommendation
Data from a systematic review and meta-analysis of RCTs suggests efficacy in the use of berberine for improving blood lipid levels in adults with dyslipidemia. No adverse events were reported; however, due to high heterogeneity and the risk of bias, additional research is needed to confirm these findings.
Key Practice Point #2: Coenzyme Q10
Recommendation
Clinical trials provide conflicting data regarding the benefit of coenzyme Q10 (CoQ10, ubiquinone, ubiquinol) for improving the lipid profile of adults with dyslipidemia. Studies reporting beneficial effects for CoQ10 on the lipid profile have been criticized as being poor quality trials due to having small sample sizes and inconsistent findings. The efficacy of CoQ10 for managing serum lipids is therefore unknown until high quality studies are published.
Key Practice Point #3: Garlic
Recommendation
Data from systematic reviews and meta-analyses provide inconsistent evidence for the effectiveness of garlic supplements on blood lipid levels, with pooled results showing no effect to a 5% decrease in total cholesterol levels and no effect to a 6% decrease in LDL-C levels. Reported effects appear to be greater in individuals with baseline hypercholesterolemia. Data from clinical trials consistently report no overall effects of garlic supplements on HDL-C levels; however, garlic oil compared to other garlic preparations was shown to significantly increase HDL-C. Reported mild adverse effects of garlic include breath and body odour and gastrointestinal disturbances. Garlic has anticoagulant and antiplatelet effects and is not recommended for individuals taking warfarin, aspirin or other anticoagulant medication.
The use of garlic supplements for the management of hypercholesterolemia may warrant discussion with clients with consideration given to the trade-offs between the potential modest beneficial effects on total and LDL-C levels with mild side-effects.
To read the full practice question, including recommendations for guggul, lecithin, niacin, policosanol, red clover, red yeast rice and rice bran oil, click here.