Age-related Eye Diseases and Dietary Patterns
The Question
What dietary patterns reduce the risk or slow the progression of age-related eye diseases (e.g. macular degeneration, glaucoma, diabetic retinopathy, cataracts)?
The Recommendation
Mediterranean Dietary Pattern
A Mediterranean diet may reduce the risk and progression of age-related macular degeneration (AMD) and may protect against diabetic retinopathy. It may not have any effect on the risk for glaucoma or cataracts, although there is a general lack of evidence for these eye diseases. Evidence for dry eye syndrome is inconsistent.
Asian Dietary Pattern
An Asian dietary pattern may reduce the risk and progression of AMD.
Other Dietary Patterns
Dietary patterns that are high in grains, fish, poultry, vegetables and nuts and low in red meat may slow the progression of AMD.
The Evidence
A 2023 systematic review of 18 studies (three RCTs, 15 observational) found that a Mediterranean diet reduced the risk of the development and progression of AMD and protected against diabetic retinopathy. The authors found no effect on glaucoma or cataracts (although they noted an overall lack of research) and inconsistent results for dry eye syndrome. Results may be limited by the exclusion of studies published in a language other than English and by the heterogeneity of study designs, measurement of adherence to a Mediterranean diet, and criteria used to diagnose each of the age-related eye diseases.
Results from a 2019 systematic review of two observational studies suggested that an Asian dietary pattern and dietary patterns low in red meat and high in grains, fish, poultry, vegetables and nuts reduced the risk of the development and progression of AMD while a Western dietary pattern increased the risk. Results may be limited by the low number of studies conducted on this topic and by recall bias associated with the use of food frequency questionnaires to assess dietary intake.
Grade of Evidence C
The Remarks
In the included studies, a Mediterranean dietary pattern encouraged high intakes of vegetables, nuts, cereal grains, fruit, beans and olive oil; a moderate intake of dairy products, poultry, fish and red wine; and a low intake of red meat and sugary foods. An Asian dietary pattern was high in fruit, vegetables (including tomatoes), legumes, whole grains and seafood. A Western dietary pattern was high in red and processed meat, eggs, high-fat dairy products, fried potatoes and refined grains.
Mediterranean and Asian dietary patterns may promote eye health because they emphasize foods that are high in antioxidants (e.g. vegetables, fruit, whole grains, nuts, seafood) and limit pro-inflammatory foods (e.g. red meat, sugary foods), thereby reducing the inflammation that can contribute to several age-related eye diseases.
To see the full practice question, including the Evidence Statements, Comments and References, click here.