Muscle Cramps - The Latest Evidence on Nutrients and Beverages that Exacerbate or Alleviate?
The Question
What nutrients or beverages exacerbate or alleviate muscle cramps?
The Recommendation
Older Adults
Fair evidence from a systematic review suggests that magnesium supplements (336 to 520 mg elemental magnesium/day) taken for four weeks likely do not prevent or treat idiopathic leg cramps in older adults (mean age >65 years). However, fair evidence from an RCT published after the systematic review suggests that magnesium supplements (226 mg elemental magnesium/day) taken for two months may reduce the frequency or severity of nocturnal cramps in adults (mean age 57 years). More evidence is needed before a recommendation can be made.
Pregnancy
Limited evidence suggests an unclear effect of magnesium supplements on pregnancy-related cramps.
Liver Cirrhosis
A conclusion about magnesium supplements for cramps in individuals with cirrhosis is not possible because evidence is extremely limited.
The Recommendation
Limited evidence suggests that electrolyte beverages (e.g. sports drinks) protect against and reduce pain associated with exercise-induced muscle cramps in healthy young adults. Limited evidence also suggests that pickle juice may shorten the duration of exercise-induced muscle cramps in healthy young adults and may reduce the severity of cramps in adults with cirrhosis.
The Recommendation
Liver Cirrhosis
Limited evidence, mostly from prospective single-arm studies, suggests that taurine, L-carnitine, branched-chain amino acids (BCAAs), vitamin D and zinc show promise for reducing the frequency, severity and/or duration of muscle cramps in individuals with liver cirrhosis, but results may not be applicable to other populations. Evidence for vitamin E is contradictory. There is not enough high quality research to make a recommendation.
Hemodialysis
Limited evidence from one small RCT suggests that vitamin K2 may reduce the frequency, severity and duration of muscle cramps experienced during hemodialysis. Additional high quality research is needed before a recommendation can be made.
The Recommendation
Limited evidence from a small observational study suggests that drinking alcohol at least once a week is associated with nocturnal leg cramps in older adults (≥60 years) but it is unclear if avoiding alcohol reduces the risk of cramps.
To see the full practice question, including the Evidence Summary, Remarks, Evidence Statements, Comments, Rationale and References, click here.
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