Gastrointestinal System - Intestinal Permeability
Background
Gastrointestinal System - Intestinal Permeability Background
Disease Etiology
Intestinal permeability (IP), sometimes referred to as ‘leaky gut’ syndrome, is defined as a change in the permeability (compared to normal) in the intestine leading to an impaired mucosal barrier (1). Antigens and macromolecules pass through the intestinal barrier initiating an immune response, ultimately influencing immune tolerance and changes in immunity. Changes to IP have been attributed to several chronic inflammatory diseases and disorders; however, the vast majority of
Intestinal permeability (IP), sometimes referred to as ‘leaky gut’ syndrome, is defined as a change in the permeability (compared to normal) in the intestine leading to an impaired mucosal barrier (1). Antigens and macromolecules pass through the intestinal barrier initiating an immune response, ultimately influencing immune tolerance and changes in immunity. Changes to IP have been attributed to several chronic inflammatory diseases and disorders; however, the vast majority of